without gain you have no image. how many OP amps are before ADC 😊 in fact the photo diode voltage/charge isnt the voltage thats even sampled.
An operational amplifier is a DC-coupled high-gain electronic voltage amplifier with a differential input and, usually, a single-ended output. In this configuration, an op amp produces an output potential that is typically 100,000 times larger than the potential difference between its input terminals.
ISO IS THE GAIN
The truth is, it’s much easier than that. ISO is the gain that is applied to the amount of light your camera sensor has “recorded”. And being exactly that, the gain, it has nothing to do with exposure. It is applied by the cameras processor long after the shutter has closed.
Nevertheless, the gain has an influence on image brightness
Summary: higher gain (ISO) – brighter image