For maximising the quality of the raw data you need to maximise the exposure* within your DOF and blur constraints without clipping important highlights. In that case ISO is irrelevant for me, as long as important highlights are not clipped because I set the final image lightness in post, not in camera.
If I am ETTR'ing I lock in base ISO, all other times ISO is set to Auto for the above reason.
* exposure - amount of light striking the sensor per unit area while the shutter is open
** optimal exposure - the maximum exposure* within dof and motion blur requirements without clipping important highlights.
*** under exposed - more exposure* could have been added with the DOF and blur constraints still being met without clipping important highlights.