I forgot that my Tamron 150-600mm VC g2 requires fine-tuning to each camera. I saw I was having some issues and I just set a quick AF fine-tune in the D850 to adjust for what I was seeing at around 500mm:

So one more thing on my to-do list with this camera will be to get out the Tamron dock and make the fifteen adjustments for this lens, along with three each for my Tamron 45mm f/1.8 VC and 85mm f/1.8 VC.
I feel I have the workflow mostly dialed in, though it's always subject to change. For now I just applied my D500 defaults in NX-D, applied Topaz NR to three other files just like the one above (ISO 6400 and heavily cropped makes for a bit of noise that I wanted dealt with), and then I set a tonal curve in a luminance layer, and saved the work as a JPEG. The end results were coming out of my computer in under a minute per file.
